The aim of this work is to place suffering at the center of socio-critical considerations. It initially starts with the criticism of the concept of alienation which can be found in a long tradition within social and political philosophy. The orientation towards concrete experiences of suffering allows conclusions on the current and concrete socio-cultural limits of human formability and adaptability. On the one hand, the reference to suffering ensures that the real human being is indeed at the center of such investigations and no abstraction, which helps avoid overly idealistic speculations. On the other hand, suffering shows up at the nodal point of bio-psycho-sociocultural dimensions and has to be interpreted in this specific interconnect...